Ineffectiveness of procalcitonin-guided antibiotic therapy in severely critically ill patients: A meta-analysis

Procalcitonin-guided antibiotic therapy in critically ill adults: a meta-analysis

BACKGROUND As a novel biomarker of inflammation, procalcitonin (PCT) has proven useful to guide antibiotic therapy in intensive care unit (ICU). However, there are controversial on mortality. The aim of this study was to evaluate the utility of PCT-guided antibiotic therapy in critically ill adults and determine whether studies are sufficient. METHODS A systematic search in PubMed, Embase and...

Impact of Procalcitonin (PCT)-Guided Antibiotic Therapy on Mortality in Critically Ill Patients: A Systematic Review and Meta-Analysis of 18 Randomized Controlled Trials

Procalcitonin-guided antibiotic therapy in intensive care unit patients: a systematic review and meta-analysis

BACKGROUND Serum procalcitonin (PCT) concentration is used to guide antibiotic decisions in choice, timing, and duration of anti-infection therapy to avoid antibiotic overuse. Thus, we performed a systematic review and meta-analysis to seek evidence of different PCT-guided antimicrobial strategies for critically ill patients in terms of predefined clinical outcomes. METHODS We searched for re...

Biomarker-guided antibiotic therapy in adult critically ill patients: a critical review

Biomarkers of infection, namely C-reactive protein and procalcitonin (PCT), are potentially useful in the diagnosis of infection as well as in the assessment of its response to antibiotic therapy. C-reactive protein variations overtime appears to have a good performance for the diagnosis of infection. Procalcitonin shows a better correlation with clinical severity. In addition, to overcome the ...

the comparison of procalcitonin guidance administer antibiotics with empiric antibiotic therapy in critically ill patients admitted in intensive care unit

the empiric antibiotic therapy can result in antibiotic overuse, development of bacterial resistance and increasing costs in critically ill patients. the aim of the present study was to evaluate the effect of procalcitonin (pct) guide treatment on antibiotic use and clinical outcomes of patients admitted to intensive care unit (icu) with systemic inflammatory response syndrome (sirs).  a total ...